I always though it was grit, dirt or mould in the glass wiper trim (the faux suede wipe-strip-come-seal that the glass wipes on as it goes down)
Although i haven't had a problem yet, my old 330i went green & mouldy in there and left dirty marks on the glass, so a jug of soapy water and a toothbrush soon cleaned it all up, plenty of clean water to flush out the grit etc. (but not to powerful that it gushes inside the door)
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